46 patients committed (Part A+B). 2→6 US sites (staggered). Part C optional. Generated from CSV. | April 2026
| Cohort | Part | Priming | Full Dose | Schedule | Active? | Patients | Opens |
|---|---|---|---|---|---|---|---|
| A1 | A | — | 0.03 mg | Q2W | 1 | M0 | |
| A2 | A | — | 0.09 mg | Q2W | 1 | M1 | |
| A3 | A | — | 0.27 mg | Q2W | 1 | M2 | |
| A4 | A | — | 0.81 mg | Q2W | 2 | M3 | |
| A5 | A | — | 2.43 mg | Q2W | 2 | M4 | |
| B1 | B | 2mg | 4mg | Q2W | 3 | M7 | |
| B2 | B | 2mg | 10mg | Q2W | ACTIVE | 9 | M9 |
| B3 | B | 2mg | 30mg | Q2W | ACTIVE | 9 | M11 |
| B4 | B | 2mg | 70mg | Q2W | ACTIVE | 9 | M13 |
| B5 | B | 2mg | 100mg | Q2W | ACTIVE | 9 | M15 |
| TOTAL (Part A: 7, Part B: 39) | 46 | ||||||
gantt
title CB-101-001 Phase 1 Enrollment
dateFormat YYYY-MM-DD
axisFormat %b %y
todayMarker off
section Part A
A1-A5 accelerated titration (7 pts) :a_all, 2027-06-01, 2027-12-01
SRC review + priming :done, a_src, 2027-12-01, 2028-01-01
section Part B
B1 de novo (3 pts, 4mg) :b1_dn, 2028-01-01, 2028-02-01
B2 de novo (3 pts, 10mg) :b2_dn, 2028-03-01, 2028-04-01
B2 backfill (6 pts) :b2_bf, 2028-04-01, 2028-08-01
B3 de novo (3 pts, 30mg) :b3_dn, 2028-05-01, 2028-06-01
B3 backfill (6 pts) :b3_bf, 2028-06-01, 2029-01-01
B4 de novo (3 pts, 70mg) :b4_dn, 2028-07-01, 2028-08-01
B4 backfill (6 pts) :b4_bf, 2028-08-01, 2029-02-01
B5 de novo (3 pts, 100mg) :b5_dn, 2028-09-01, 2028-10-01
B5 backfill (6 pts) :b5_bf, 2028-10-01, 2029-03-01
section Part C (Optional)
Randomized dose optimisation (if activated) :crit, c_all, 2029-02-01, 180d
section Milestones
FPD :milestone, m_fpd, 2027-06-01, 0d
ASH 2028 :milestone, m_ash, 2028-12-01, 0d
ASCO 2029 :milestone, m_asco, 2029-06-01, 0d
Auto-generated from cb101-phase1-enrollment-projection.csv. Do not edit HTML directly.
Run: python3 tools/build_enrollment_visual.py --password CodingBio2026! --open