CB-101 Phase 1 — Series A Plan

46 patients committed (Part A+B). 2→9 US sites (staggered). Part C optional. Generated from CSV. | April 2026

Cohort Overview

Cohort	Part	Priming	Full Dose	Schedule	Active?	De Novo	Backfill	Total	Opens
A1	A	—	0.03 mg	Q2W		1	0	1	M0
A2	A	—	0.09 mg	Q2W		1	0	1	M1
A3	A	—	0.27 mg	Q2W		1	0	1	M2
A4	A	—	0.81 mg	Q2W		1	1	2	M3
A5	A	—	2.43 mg	Q2W		1	1	2	M4
B1	B	—	4 mg	Q2W		3	0	3	M7
B2	B	—	10 mg	Q2W	ACTIVE	3	6	9	M9
B3	B	—	30 mg	Q2W	ACTIVE	3	6	9	M11
B4	B	—	70 mg	Q2W	ACTIVE	3	6	9	M13
B5	B	—	100 mg	Q2W	ACTIVE	3	6	9	M15
Part C — Randomized (post-trigger M19). Not committed.
C1	C	2 mg	100 mg	Q2W	ACTIVE	—	—	20	M20+
C2	C	2 mg	30 mg	Q2W	ACTIVE	—	—	20	M20+
C3	C	2 mg	100 mg	Q4W	ACTIVE	—	—	20	M20+
Part A+B (committed)						15	24	46
+ Part C (if triggered)						—	—	60
Total A+B+C								106

Program Timeline (Gantt)

gantt
    title CB-101-001 Phase 1 Enrollment
    dateFormat YYYY-MM-DD
    axisFormat %b %y
    todayMarker off

    section Part A
    A1-A5 accelerated titration (7 pts) :a_all, 2027-06-01, 2027-12-01
    SRC review + priming :done, a_src, 2027-12-01, 2028-01-01
    section Part B
    B1 de novo (3 pts, 4mg) :b1_dn, 2028-01-01, 2028-02-01
    B2 de novo (3 pts, 10mg) :b2_dn, 2028-03-01, 2028-04-01
    B2 backfill (6 pts) :b2_bf, 2028-04-01, 2028-08-01
    B3 de novo (3 pts, 30mg) :b3_dn, 2028-05-01, 2028-06-01
    B3 backfill (6 pts) :b3_bf, 2028-06-01, 2029-01-01
    B4 de novo (3 pts, 70mg) :b4_dn, 2028-07-01, 2028-08-01
    B4 backfill (6 pts) :b4_bf, 2028-08-01, 2029-02-01
    B5 de novo (3 pts, 100mg) :b5_dn, 2028-09-01, 2028-10-01
    B5 backfill (6 pts) :b5_bf, 2028-10-01, 2029-03-01
    section Part C (Optional)
    Randomized dose optimisation (if activated) :crit, c_all, 2029-02-01, 180d
    section Milestones
    FPD :milestone, m_fpd, 2027-06-01, 0d
    ASH 2028 :milestone, m_ash, 2028-12-01, 0d
    ASCO 2029 :milestone, m_asco, 2029-06-01, 0d

Cumulative Enrollment by Cohort

Active Dose Patients & Follow-Up

Median Follow-Up (Active Dose)

Sites & Monthly Enrollment

Cash Position vs Data Maturity (Board View)

Cumulative Spend vs Active Dose Patients

Monthly Spend Breakdown

Auto-generated from cb101-phase1-enrollment-projection.csv. Do not edit HTML directly.
Run: python3 tools/build_enrollment_visual.py --password CodingBio2026! --open

CB-101 Dashboard

CB-101-001 Phase 1 — Series A Plan